Basophils in skin inflammation

Basophils in skin inammation

Basophils represent less than 1 of peripheral blood leukocytes. Under physiological conditions, basophils principally circulate in peripheral blood, while mast cells reside in peripheral tissues. Like mast cells, they express the high a‹nity IgE receptor on their cell surface and release chemical mediators. Because of morphological and functional similarities, basophils have long been conside...

Basophils promote innate lymphoid cell responses in inflamed skin.

Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized by the accumulation of basophils and group 2 innate lymphoid cells (ILC2s) in inflamed skin lesions. Although murine studies have demonstrated that cutaneous basophil and ILC2 responses are dependent on thymic stromal lymphopoietin, whether these cell populations interact to regulate the developmen...

Basophils are essential initiators of a novel type of chronic allergic inflammation Short title: basophils initiate chronic allergic inflammation

Kazushige Obata, Kaori Mukai, Yusuke Tsujimura, Kenji Ishiwata, Yohei Kawano, Yoshiyuki Minegishi, Naohiro Watanabe, and Hajime Karasuyama Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan, Department of Tropical Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461...

Are basophils identifiable in histological sections of cat skin?

Chronic Inflammation in Skin Malignancies

Introduction Inflammation is characterized by the infiltration of plasma and leukocytes to tissues that undergo disrupted homeostasis [1]. The causes of inflammation range from pathogenic infection, tissue injury to tissue stress and malfunction [1]. Inflammatory process is critical for normal physiological responses against infection and tissue damage, and promotes the clearance of invading pa...